March 16th, 2010 by admin

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Phoebe is a Channel Island Allen (S.s. sedentarius) hummingbird in Orange County, California.

March 16th, 2010 by admin

CELL DEATH AND DIFFERENTIATION

April 2010 Volume 17 Number 4, pp 565 – 732

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As a registered user of Cell Death & Differentiation, you will be highly
interested in the content published online in Cell Death & Disease.

http://links.ealert.nature.com/ctt?kn=33&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0

Focusing solely on the translational implications of cell death, Cell Death & Disease
keeps with the high standards of Cell Death & Differentiation, offering fast publication
and peer-review by the same renowned editorial team:

-Guido Kroemer
-Gerry Melino
-Pierluigi Nicotera

Register online today at http://links.ealert.nature.com/ctt?kn=68&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0
and access the hottest content from Cell Death & Disease.

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EDITORIAL
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Granzymes in disease: bench to bedside
D J Granville
http://links.ealert.nature.com/ctt?kn=35&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0

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REVIEWS
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Granzymes and perforin in solid organ transplant rejection
J C Choy
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=29&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0

The role of perforin and granzymes in diabetes
H E Thomas, J A Trapani and T W H Kay
Abstract: http://links.ealert.nature.com/ctt?kn=47&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=44&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0

Control of granzymes by serpins
D Kaiserman and P I Bird
Abstract: http://links.ealert.nature.com/ctt?kn=41&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=39&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0

Granzymes in age-related cardiovascular and pulmonary diseases
A Hendel, P R Hiebert, W A Boivin, S J Williams and D J Granville
Abstract: http://links.ealert.nature.com/ctt?kn=52&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=50&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0

Perforin deficiency and susceptibility to cancer
A J Brennan, J Chia, J A Trapani and I Voskoboinik
Abstract: http://links.ealert.nature.com/ctt?kn=88&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=16&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0

Granzymes in cancer and immunity
S P Cullen, M Brunet and S J Martin
Abstract: http://links.ealert.nature.com/ctt?kn=15&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=14&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0

Granzyme B cleavage of autoantigens in autoimmunity
E Darrah and A Rosen
Abstract: http://links.ealert.nature.com/ctt?kn=11&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=10&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0

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ORIGINAL PAPERS
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Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo
I Lambertz, D Nittner, P Mestdagh, G Denecker, J Vandesompele, M A Dyer and J-C Marine
Abstract: http://links.ealert.nature.com/ctt?kn=8&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=5&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0

Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death
E Lafont, D Milhas, S Carpentier, V Garcia, Z-X Jin, H Umehara, T Okazaki, K Schulze-Osthoff, T Levade, H Benoist and B Segui
Abstract: http://links.ealert.nature.com/ctt?kn=1&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=22&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0

Cytomegaloviruses inhibit Bak- and Bax-mediated apoptosis with two separate viral proteins
M Cam, W Handke, M Picard-Maureau and W Brune
Abstract: http://links.ealert.nature.com/ctt?kn=25&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=26&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0

The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival
R Kang, D Tang, N E Schapiro, K M Livesey, A Farkas, P Loughran, A Bierhaus, M T Lotze and H J Zeh
Abstract: http://links.ealert.nature.com/ctt?kn=40&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=38&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0

PI3K p110[alpha] and p110[beta] have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts
R W Matheny and M L Adamo
Abstract: http://links.ealert.nature.com/ctt?kn=46&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=42&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0

Pim-1 controls NF-[kappa]B signalling by stabilizing RelA/p65
K Nihira, Y Ando, T Yamaguchi, Y Kagami, Y Miki and K Yoshida
Abstract: http://links.ealert.nature.com/ctt?kn=30&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0

IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells
J Gao, M Senthil, B Ren, J Yan, Q Xing, J Yu, L Zhang and J H Yim
Abstract: http://links.ealert.nature.com/ctt?kn=37&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=34&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0

Studies of the molecular mechanism of caspase-8 activation by solution NMR
N Keller, M G Grutter and O Zerbe
Abstract: http://links.ealert.nature.com/ctt?kn=56&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=57&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0

NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response
T E Graber, S D Baird, P N Kao, M B Mathews and M Holcik
Abstract: http://links.ealert.nature.com/ctt?kn=59&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=64&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0

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BOOK REVIEW
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Cell Death
J P Medema, H Walczak, M Hahne and V de Laurenzi
http://links.ealert.nature.com/ctt?kn=62&m=34701488&r=MTc2MDI3ODg3MwS2&b=2&j=Njg5ODE2NTAS1&mt=1&rt=0

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Committed to publishing high quality, independently peer-reviewed research
and review material, Cell Death & Disease further defines and shapes the
field of cell death and disease.
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Submit your paper today and be part of this exciting new online journal from NPG.
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March 16th, 2010 by admin

Committee… Location…  Programme… Registration Info…  Sponsors…   We are pleased to announce… Record number of abstracts received! The Thirteenth Annual Vision Research Conference has received a record number of abstracts this year. Leading world experts will share the latest research on retinal ganglion cells at this highly acclaimed meeting. The full speaker line-up is available to view here. REGISTER TODAY Don’t miss out. Due to the popularity of this event delegate spaces are filling up fast. If you have not yet registered and would like to attend please register your attendance using the online registration system here. By registering online before the conference you can save up to $60 on your registration fee. Registration includes: Access to all conference sessions Access to poster areas Abstract book available at the conference and conference documentation Mid-session refreshments as scheduled in the conference programme A Special issue of Vision Research containing original papers by the invited speakers, to be mailed to all registered delegates after the conference Further registration information is available here. WHO IS THE CONFERENCE AIMED AT This conference is ideal for all those who hold an interest in: Signal processing by retinal ganglion cells Photosensitive ganglion cells Ganglion cell development and axonal targeting Optic nerve damage and regeneration Mechanisms of ganglion cell death/animal models Pathogenesis/neuro-protection for ganglion cells Gene defects associated with ganglion cell disease Novel therapeutic approaches in glaucoma The Thirteenth Annual Vision Research Conference series is a two day satellite meeting prior to 2010 ARVO. It is organized by Elsevier, publishers of Vision Research, and is co-sponsored by ARVO, the Association for Research in Vision and Ophthalmology. Remember – by registering online before the conference you can save up to $60 and it only takes a few minutes of your time to fill in your details.     ORGANISERS T. Wensel, Baylor College of Medicine, USA W. Baehr, University of Utah, USA S. Wu, Baylor College of Medicine, USA Organised and sponsored by Vision Research, Elseviers international journal for Functional Aspects of Vision. Co-sponsored by ARVO the Association for Research in Vision and Ophthalmology.   CONFERENCE SECRETARIAT Amy Hill, Elsevier, UK         Data Protection Notice: This e-mail has been sent to manojhind2001us1.stemcell@blogger.com from Elsevier Ltd., The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, registered in England with registered number 1982084, using smartFOCUS DIGITAL’s technology and platform. To ensure delivery to your inbox (not bulk or junk folders), please click here to add our address to your safe senders list. You are receiving this e-mail because you are a registered user of ScienceDirect® and have consented to receive information about related products. If you do not wish to receive calls for papers for Elsevier Conferences, you can visit this page to Unsubscribe, enter your email address, and press the submit button and you will be unsubscribed. To update your ScienceDirect profile please go to the ScienceDirect website, login with your username and password and amend your preferences. Elsevier respects your privacy and does not disclose, sell or rent your personal information to any non-affiliated third parties without your consent, except as may be stated in the Elsevier Privacy Policy. Please visit this page to see smartFOCUS DIGITAL’s Privacy Policy. For all enquiries, problems or suggestions regarding this service, please contact: conferenceinfo@elsevier.com. Copyright © 2010 Elsevier Ltd. all rights reserved. ScienceDirect® is a registered trademark of Elsevier B.V.

March 15th, 2010 by admin

A talk on intellectual property and social networks for The Digital Researcher: Managing your networks and building your profile

March 15th, 2010 by admin

A talk on intellectual property and social networks for The Digital Researcher: Managing your networks and building your profile

March 13th, 2010 by admin

March 13th, 2010 by admin

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Copyright © 2009 AlphaMed Press Published on behalf of AlphaMed Press This Publication Alert is being sent to individuals who requested receipt of this information. For additional details, see the bottom of this message. Stem Cells Express (Accepted Articles) Tissue-Specific Stem Cells Phagocytosis of Apoptotic Cells Modulates Mesenchymal Stem Cells Osteogenic Differentiation to Enhance IL-17 and RANKL Expression on CD4+ T cells (p N/A) Gloria Hoi Wan Tso, Helen Ka Wai Law, Wenwei Tu, Godfrey Chi Fung Chan, Yu Lung Lau Accepted Article Online: Mar 10 2010 9:36AM DOI: 10.1002/stem.406 A New Concept Underlying Stem Cell Lineage Skewing That Explains the Detrimental Effects of Thiazolidinediones on Bone (p N/A) Claudia Bruedigam, Marco Eijken, Marijke Koedam, Jeroen van de Peppel, Ksenija Drabek, Hideki Chiba, Johannes P. T. M. van Leeuwen Accepted Article Online: Mar 8 2010 11:07AM DOI: 10.1002/stem.405 This message is sent to subscribers and alert registrants for Stem Cells. To UNSUBSCRIBE from future mailings go to The Stem Cells Express Alert list. If you have any questions or concerns about this message, please contact lwoo@wiley.com. Do not reply directly to this message. Wiley InterScience is a division of:      John Wiley & Sons, Inc.  |  111 River Street  |  Hoboken, NJ 07030      Phone: 800-225-5945  |  Fax: 800-605-2665  |  www.wiley.com

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March 13th, 2010 by admin

Committee… Location…  Speakers… Registration Info…  Symposia…   Full Programme Brochure now available Download your copy here INTRODUCTION Developments in functional genomics technologies together with the expanding concept of systems biology have led to exciting possibilities for the understanding of disease mechanisms. Following three highly successful conferences in Prague, Oslo and Innsbruck this conference will bring together world leaders with 13 plenary speakers and 36 symposia speakers discussing the challenges ahead and the technologies that will lead to novel solutions. 2010 topics include: Whole genome associations Comparative genomics RNomics & miRNA Proteomics Epigenetics Regulatory networks Systems biology Personalised medicine Oncogenomics Neurogenomics Lipidomics Bioinformatics High throughput technologies Affinity proteomics Biobanking   CONFERENCE HIGHLIGHTS Parallel Symposia, hosted in collaboration with the European Commission and Directorate of Health. With sessions from the following consortia: AffinityProteome, AtheroRemo, BBMRI, ENFIN, ELIXIR, HEROIC, LIPIDOMICNET, LUPA, PROSPECTS, READNA, SIROCCO and SYBILLA. Find out more at http://www.esffg2010.org/symposia.asp A ’sold out’ exhibition, featuring exhibitors from bioinformatics, research, software, genomic services and much more. View the latest exhibitors at http://www.esffg2010.org/exhibitors.asp Over 40 prestigious, international speakers discussing the latest developments in functional genomics and disease. View the full list of speakers at http://www.esffg2010.org/speakers.asp   REGISTER Registration Fees Standard industry: €600 + VAT at 19% = €714.00 Author / Academic: €500 + VAT at 19% = €595.00 Students: €150 + VAT at 19% = €178.50 **Student registration forms must be accompanied by a signed letter from your head of department attesting to student status. Conference Dinner: €50 + VAT at 19% = €59.50 Conference fee includes: Lunch on Thursday, Friday & Saturday Mid session refreshments Drinks reception (Wednesday evening) Poster session receptions (Thursday & Friday evening) Optional conference dinner: An optional conference party will be held on Friday 14th April. The venue has yet to be confirmed and more information regarding this event will be posted on the website shortly.       Join us on LinkedIn, click here!   EXHIBITORS INCLUDE: Abcam Affymetrix Agilent Technologies CLC Bio Eurofins Elsevier European Science Foundation European Commission GATC Biotech AG HealthTwist Miltenyi Biotec GmbH New England Biolabs Sequenom GmbH Sigma Aldrich Thermo Scientific   LOCATION The conference will take place at the Maritim Hotel and International Congress Centre situated on the banks of the River Elbe in Dresden, Germany. Dresden has excellent road and rail links to many European cities. Dresden Airport is located 9 km from the city centre with good rail links into the city.     Data Protection Notice: This e-mail has been sent to manojhind2001us1.stemcell@blogger.com from Elsevier Ltd., The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, registered in England with registered number 1982084, using smartFOCUS DIGITAL’s technology and platform. To ensure delivery to your inbox (not bulk or junk folders), please click here to add our address to your safe senders list. You are receiving this e-mail because you are a registered user of ScienceDirect® and have consented to receive information about related products. If you do not wish to receive calls for papers for Elsevier Conferences, you can visit this page to Unsubscribe, enter your email address, and press the submit button and you will be unsubscribed. To update your ScienceDirect profile please go to the ScienceDirect website, login with your username and password and amend your preferences. Elsevier respects your privacy and does not disclose, sell or rent your personal information to any non-affiliated third parties without your consent, except as may be stated in the Elsevier Privacy Policy. Please visit this page to see smartFOCUS DIGITAL’s Privacy Policy. For all enquiries, problems or suggestions regarding this service, please contact: conferenceinfo@elsevier.com. Copyright © 2010 Elsevier Ltd. all rights reserved. ScienceDirect® is a registered trademark of Elsevier B.V.

March 12th, 2010 by admin

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Mol. Biol. Cell Table of Contents Alert

A new issue of Molecular Biology of the Cell is available online:

15 March 2010; Vol. 21, No. 6

The below Table of Contents is available online at: http://www.molbiolcell.org/content/vol21/issue6/?etoc

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Meeting Review

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Morphogenesis in Kyoto: A Confluence of Cell and Developmental Biology

Jennifer A. Zallen and Alpha S. Yap

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Cell Cycle

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Mutations in Caenorhabditis elegans him-19 Show Meiotic Defects That Worsen with Age   A Highlights from MBoC Selection Lois Tang, Thomas Machacek, Yasmine M. Mamnun, Alexandra Penkner, Jiradet Gloggnitzer, Christina Wegrostek, Robert Konrat, Michael F. Jantsch, Josef Loidl, and Verena Jantsch Faithful meiotic chromosome segregation requires pairing, synapsis and recombination of homologous chromosomes. In mammals, chromosomal non-disjunction increases with age. A mutation in Caenorhabditis elegans him-19 mimics these age-dependent chromosome segregation defects and might therefore further our understanding of this phenomenon.

A Specific Form of Phospho Protein Phosphatase 2 Regulates Anaphase-promoting Complex/Cyclosome Association with Spindle Poles

Jorge Z. Torres, Kenneth H. Ban, and Peter K. Jackson

The anaphase-promoting complex/cyclosome (APC/C) is phosphorylated in a cell cycle dependent manner. We discovered that a specific form of PPP2 is necessary for APC/C dephosphorylation in mitosis and that this dephosphorylation event regulates the association of the APC/C with mitotic spindle poles.

Emi2 Inhibition of the Anaphase-promoting Complex/Cyclosome Absolutely Requires Emi2 Binding via the C-Terminal RL Tail   A Highlights from MBoC Selection Munemichi Ohe, Yoshiko Kawamura, Hiroyuki Ueno, Daigo Inoue, Yoshinori Kanemori, Chiharu Senoo, Michitaka Isoda, Nobushige Nakajo, and Noriyuki Sagata Both the D-box and the zinc-binding region (ZBR) of Emi2 are implicated in APC/C inhibition. This article shows that Emi2 binds the APC/C via the C-terminal tail, termed here the RL tail. The RL tail apparently promotes the inhibitory interactions of the D-box and the ZBR with the APC/C. The RL tail thus serves as a docking site for the APC/C.

Requirements and Reasons for Effective Inhibition of the Anaphase Promoting Complex Activator Cdh1   A Highlights from MBoC Selection Jonathan A. Robbins and Frederick R. Cross Inhibitory phosphorylation of Cdh1 by CDK and Polo kinase has been proposed to inactivate APC-Cdh1. Through an exact gene replacement approach, we find CDK, but not Polo, phosphorylation of Cdh1 to be a critical regulatory mechanism. APC-Cdh1 inhibits multiple aspects of spindle morphogenesis, and its activity is modulated by endogenous ACM1.

Rad17 Plays a Central Role in Establishment of the Interaction between TopBP1 and the Rad9-Hus1-Rad1 Complex at Stalled Replication Forks   A Highlights from MBoC Selection Joon Lee and William G. Dunphy This work provides novel mechanistic insights into how TopBP1 and the Rad9-Hus1-Rad1 (9-1-1) complex dock with one another at stalled replication forks. This step is necessary for the ATR-dependent activation of Chk1 during checkpoint responses.

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Cell Motility

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A Receptor-associated Protein/Phosphatidylinositol 3-Kinase Pathway Controls Pseudopod Formation

Arjan Kortholt, Parvin Bolourani, Holger Rehmann, Ineke Keizer-Gunnink, Gerald Weeks, Alfred Wittinghofer, and Peter J.M. Van Haastert

GbpD, a guanine exchange factor specific for Rap1, has been implicated in adhesion, cell polarity, and chemotaxis of Dictyostelium cells. Here it is shown that activated Rap1 directly binds to PI3K. The activation of PI3K by Rap1 and RasG regulates basal and chemoattractant-stimulated PIP3 levels and pseudopod formation.

Gq-coupled Purinergic Receptors Inhibit Insulin-like Growth Factor-I/Phosphoinositide 3-Kinase Pathway-dependent Keratinocyte Migration

Salma Taboubi, Françoise Garrouste, Fabrice Parat, Gilbert Pommier, Emilie Faure, Sylvie Monferran, Hervé Kovacic, and Maxime Lehmann

After skin wound, released growth factors and extracellular nucleotides regulate the different phases of healing, including re-epithelialization. Here, we show that, in keratinocytes, purinergic P2Y2 receptors inhibit the motogenic IGF-I/PI3K pathway. Therefore, extracellular nucleotides may play key roles during skin remodelling after wound.

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Membrane Trafficking

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Combinational Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor Proteins VAMP8 and Vti1b Mediate Fusion of Antimicrobial and Canonical Autophagosomes with Lysosomes

Nobumichi Furuta, Naonobu Fujita, Takeshi Noda, Tamotsu Yoshimori, and Atsuo Amano

Autophagy (xenophagy) degrades intracellular bacteria. The cargoes are degraded after the fusion of xenophagosomes with lysosomes. However, the molecular mechanism underlying the fusion remains unclear. Here we show that combinational SNARE proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes.

Role of the Second Cysteine-rich Domain and Pro275 in Protein Kinase D2 Interaction with ADP-Ribosylation Factor 1, Trans-Golgi Network Recruitment, and Protein Transport

Ganesh Varma Pusapati, Denis Krndija, Milena Armacki, Götz von Wichert, Julia von Blume, Vivek Malhotra, Guido Adler, and Thomas Seufferlein

The present study provides the first link between the “classical” machinery regulating protein transport at the Golgi compartment, namely ARF proteins and PKDs, and demonstrates that the direct interaction of both is crucial for efficient protein transport from the TGN to the plasma membrane.

Regulators of Vps4 ATPase Activity at Endosomes Differentially Influence the Size and Rate of Formation of Intralumenal Vesicles

Daniel P. Nickerson, Matthew West, Ryan Henry, and Greg Odorizzi

Disassembly of ESCRT-III requires Vps4 ATPase activity under the control of regulatory proteins. Described here are distinct spatiotemporal functions for Vps4 regulators, with Did2 playing a unique role in regulating MVB lumenal vesicle size and Vtal-Vps60 promoting efficient membrane scission and delivery of vesicles into the endosome lumen.

Vesicular Calcium Regulates Coat Retention, Fusogenicity, and Size of Pre-Golgi Intermediates

Marvin Bentley, Deborah C. Nycz, Ashwini Joglekar, Ismene Fertschai, Roland Malli, Wolfgang F. Graier, and Jesse C. Hay

This study establishes a role for luminal Ca²⁺ in ER/Golgi transport organelles and elucidates an effector mechanism involving the EF-hand protein ALG-2 and regulation of COPII coat retention.

The Endoplasmic Reticulum–associated Degradation of the Epithelial Sodium Channel Requires a Unique Complement of Molecular Chaperones

Teresa M. Buck, Alexander R. Kolb, Cary R. Boyd, Thomas R. Kleyman, and Jeffrey L. Brodsky

This study describes new yeast expression systems for each subunit of the heterotrimeric epithelial sodium channel (ENaC). We found that a significant amount of each subunit resides in the ER and is destroyed via ERAD. We also found that the chaperone requirements for ENaC subunit degradation were unlike any other ERAD substrate examined.

Assembly of the AAA ATPase Vps4 on ESCRT-III

Anna Shestakova, Abraham Hanono, Stacey Drosner, Matt Curtiss, Brian A. Davies, David J. Katzmann, and Markus Babst

A complex network of interactions mediates the recruitment of Vps4 to ESCRT-III and its subsequent assembly, two key steps in the ESCRT-dependent vesicle formation at the endosome. A model is presented depicting the order of events that lead to active, ESCRT-III–associated Vps4.

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Nuclear Functions

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Members of the RSC Chromatin-Remodeling Complex Are Required for Maintaining Proper Nuclear Envelope Structure and Pore Complex Localization

Laura C. Titus, T. Renee Dawson, Deborah J. Rexer, Kathryn J. Ryan, and Susan R. Wente

Genome-wide screening approaches were employed to identify factors required for nuclear pore complex structure and distribution in Saccharomyces cerevisiae. Roles were found for multiple components of the RSC complex, revealing a functional connection between proper chromatin remodeling and nuclear envelope/nuclear pore complex structure.

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Signaling

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Ras and Calcium Signaling Pathways Converge at Raf1 via the Shoc2 Scaffold Protein

Sayaka Yoshiki, Rie Matsunaga-Udagawa, Kazuhiro Aoki, Yuji Kamioka, Etsuko Kiyokawa, and Michiyuki Matsuda

Activation of Raf1 at the plasma membrane requires not only Ras activation but also an increase in Ca²⁺ concentration or inhibition of calmodulin. The Ca²⁺-dependent activation of Raf1 is abrogated by knockdown of Shoc2. We show that the Shoc2 scaffold protein modulates Ras-dependent Raf1 activation in a Ca²⁺- and calmodulin-dependent manner.

Compartmentalized Cyclic Adenosine 3′,5′-Monophosphate at the Plasma Membrane Clusters PDE3A and Cystic Fibrosis Transmembrane Conductance Regulator into Microdomains   A Highlights from MBoC Selection Himabindu Penmatsa, Weiqiang Zhang, Sunitha Yarlagadda, Chunying Li, Veronica G. Conoley, Junming Yue, Suleiman W. Bahouth, Randal K. Buddington, Guangping Zhang, Deborah J. Nelson, Monal D. Sonecha, Vincent Manganiello, Jeffrey J. Wine, and Anjaparavanda P. Naren PDE3A functionally and physically interacts with CFTR. Inhibition of PDE3A generates compartmentalized cAMP, which further clusters PDE3A and CFTR into microdomains at the plasma membrane of epithelial cells and potentiates CFTR channel function. Our findings provide insights into the important role of PDE3A in compartmentalized cAMP signaling.

Transforming Growth Factor-β1 Induces Transdifferentiation of Myoblasts into Myofibroblasts via Up-Regulation of Sphingosine Kinase-1/S1P₃ Axis

Francesca Cencetti, Caterina Bernacchioni, Paola Nincheri, Chiara Donati, and Paola Bruni

Transforming growth factor-β1 induces Smad-dependent transdifferentiation of myoblasts into myofibroblasts via up-regulation of sphingosine kinase-1/S1P₃ axis with a mechanism involving Rho/Rho kinase activation.

Vav3-deficient Mice Exhibit a Transient Delay in Cerebellar Development

Celia Quevedo, Vincent Sauzeau, Mauricio Menacho-Márquez, Antonio Castro-Castro, and Xosé R. Bustelo

Vav proteins are phosphorylation-dependent Rho/Rac exchange factors that have usually been associated with immune- and cardiovascular-related functions. In this paper, Quevedo et al. demonstrate that Vav3 plays important, although transient, pleiotropic roles during the postnatal development of the cerebellum.

Protein Phosphatase 2A Reactivates FOXO3a through a Dynamic Interplay with 14-3-3 and AKT

Amrik Singh, Min Ye, Octavian Bucur, Shudong Zhu, Maria Tanya Santos, Isaac Rabinovitz, Wenyi Wei, Daming Gao, William C. Hahn, and Roya Khosravi-Far

This article describes a functional interaction between PP2A and FOXO3a in which PP2A promotes rapid dephosphorylation of FOXO3a at its conserved AKT phosphorylation sites, leading to FOXO3a dissociation from 14-3-3, nuclear translocation, and transcriptional activation in response to inhibition of PI3K signaling.

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Meeting Review

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Morphogenesis in Kyoto: A Confluence of Cell and Developmental Biology

Jennifer A. Zallen and Alpha S. Yap

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